For a shipping quote, check the box and the bottom and provide us your shipping information. The present invention combats this problem, with hydroquinone compositions in the neutral pH range, preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. It is a reducing agent that is reversibly oxidized to semiquinone and quinone. hydroquinone, 1,4-benzenediol, quinol, 1,4-dihydroxybenzene, p-benzenediol, 4-hydroxyphenol, p-hydroquinone, p-hydroxyphenol, p-dihydroxybenzene, benzoquinol, Electrophoresis, Western Blotting and ELISA, Chromatography and Mass Spectrometry Reagents, Laboratory Syringe Needles and Accessories, Lab Coats, Aprons, and Other Safety Apparel, Sharps Disposal Containers and Accessories, Classroom Laboratory Supplies and Consumables, Applied Biosystems TaqMan Assay and Arrays Search Tool, Applied Biosystems TaqMan Custom Assay Design Tools, Applied Biosystems Custom qPCR Primers and TaqMan Probes Tool, Chemical Storage and Management Resource Center, Solubility in water: 70g/L in water (20C). This compound is gathered from the beaver's castor sacs.[35]. You can expect to hear back from a ChemPoint product specialist within 1 business hour. Environ. The Molecular Weight is 110.11 g/mol. The composition is preferably formulated in separate phases as designated below. Part of Springer Nature. Consistent with a condensation reaction, water was determined to be the primary byproduct. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Although about 0.01% sodium metabisulfite without magnesium ascorbyl phosphate may not color stabilize an about 4% hydroquinone composition, and about 0.5% magnesium ascorbyl phosphate without sodium metabisulfite may not either, the combination of sodium metabisulfite and magnesium ascorbyl phosphate in these percentages is effective to stabilize the color of the about 1% to about 12%, about 2% to about 10%, preferably about 2% to about 8% and more preferably about 3% to about 4% and most preferably 4% hydroquinone composition. Without being limited to the mechanism of this discoloration, it is believed that the discoloration may be caused at least in part by oxidation of the hydroquinone. Solubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol Features & Benefits Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMO Extremely low vapor pressure USP Grade European Pharma Grade Drug master file available upon request Applications I can only tell you how to mix the powder solution to the liquid solvent. 132, 165172 (2018), X. Li, Q. Yin, W. Chen, J. Wang, J. Chem. Airborne hydroquinone may be oxidized to quinone at ordinary . We will respond to you shortly. Hydroquinone IS a white crystalline substance when pure and is highly soluble in water. All Rights Reserved, View All Eastman Hydroquinone USP Articles. A3, Free format text: Have an order or account question, find answers in our Online Support articles. 2017-02-16T10:10:56+01:00 It is highly soluble in water (70 g/litre at 25 C) and the log n-octanol/water partition coefficient is 0.59. A2, Designated state(s): wG xR^[ochg`>b$*~ :Eb~,m,-,Y*6X[F=3Y~d tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:O:8uJqnv=MmR 4 65, 5786 (1998), Y.-H. Zhang, Trends Analyt. The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. Do not put this product in the microwave. Eastman Hydroquinone, USP, meets or exceeds the requirements of the United States Pharmacopoeia and is produced under conditions of current good manufacturing practices (cGMP). 322, 4855 (2012), K. Tamura, T. Kasuga, T. Nakagawa, Fluid Phase Equilib. I understand the concentrations are high but I have used them before, its just too expensive to keep buying from a compounding pharmacy. Boucif Belhachemi. Hydroquinone undergoes oxidation under mild conditions to give benzoquinone, process which is reversible. 0000002379 00000 n By acting as a free radical scavenger, hydroquinone serves to prolong the shelflife of light-sensitive resins such as preceramic polymers.[18]. The solubilities in binary and ternary systems of hydroquinone (1,4-dihydroxybenzene) and p-quinone (1,4-benzoquinone) in supercritical carbon dioxide were measured in the pressure range 10.0 to 35.0 MPa at temperatures of 333, 348 and 363 K.In binary systems, the solubility of hydroquinone was three orders of magnitude lower than that of p-quinone. Anal. You take the cream, put it in a container, take the powder measurement and add it. Phase A is added to the tank, which is held at a temperature of from about 70 to about 75 C, and in which a CO. Hydroquinone Safety Data Sheet according to Federal Register / Vol. Res. The present invention is not to be limited by any mechanism described in the specification, because it is defined by the claims. Some documentation and label information may refer to the legacy brand. PubMedGoogle Scholar. It is a reducmg agent that is reversibly oxidized to semiquinone and quinone. Thus, while cationic salts of acidic ascorbyl esters, preferably magnesium ascorbyl phosphate and aminopropyl ascorbyl phosphate, have beneficial antioxidant effects on the skin, the combination with hydroquinone in the invention results in a compatible and stable composition. The natural pH for conventional hydroquinone compositions is acidic, generally less than about 4 even though this is harsh to the skin and to other components of the product. 0000053439 00000 n So, does anybody know of another solvent I could use that has a higher solubility and is relatively non-toxic. They may also include ingredients with other therapeutic actions, such as anti-inflammatories, antibiotics, exfoliants and peels. Cite this article. Cookie Notice SAS Anti-ox booster 1% 0.3g. 29(3): 283-330, 1999. A common route involves hydroxylation of phenol. Also in this embodiment is a cationic salt of acidic ascorbyl esters, which further helps to maintain the acceptable color desired in the hydroquinone composition. Your document download will begin shortly. [O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(O)=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1, OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C, Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE, CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O, [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] dihydrogen phosphate, [Na+]. Hydroquinone is considered to be readily biodegrable and photodegradable. Retinoid compositions, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) are known to be effective in improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. uuid:a150f3fd-7f22-4439-aa26-6f445f4017e5 Recent pieces of . N')].uJr Eng. Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent. Additionally, a water-soluble antioxidant, preferably a sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, may be helpful in stabilizing the hydroquinone composition. You take the cream, put it in a container, take the powder measurement and add it. n3kGz=[==B0FX'+tG,}/Hh8mW2p[AiAN#8$X?AKHI{!7. Lastly, I'd like to add benzoic acid for preservation purposes. Thank you for your inquiry and interest in ChemPoint. 230, 176183 (2005), A. Apelblat, E. Manzurola, N. A. Balal, J. Chem. This range of pH has been preferred for hydroquinone compositions, because it has been believed that the hydroquinone is less likely to excessively discolor under acid conditions. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C 6 H 6 O 2; molecular weight is 110.0. Pigmentation disorders can take a variety of forms like hyperpigmentation and hypopigmentation, such as melasma (dark patches experienced in pregnancy), liver spots (which often develop with age), as a side effect of birth control pills, and as a persistent result of acne, bums, bites and other skin injuries, and vitiligo. If you have any specific questions, please include them in the comments section. Antioxidants, preferably sulfites, including but not limited to sulfites, bisulfites, metabisulfites, their salts, and their derivatives, most preferably sodium metabisulfite, have been used to stabilize certain compositions, which have included hydroquinone. HMkA+"c>jZ^ho=81NW;]Ib;+i#iFArHpz). `9F6~qg3]0,#!V9Q> p=|h| The disodium diphenolate salt of hydroquinone is used as an alternating comonomer unit in the production of the polymer PEEK. Toxicol. It would be desirable to combine the pigmentation disorder treatment with this skin benefit ingredient in one composition. Such carriers are widely known in the art and deliver the composition's ingredients to the skin without excessive degradation, inactivation or other unwanted interaction. [17], An important reaction is the conversion of hydroquinone to the mono- and diamine derivatives. Most preferably, when both a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, are present, the color of the hydroquinone composition is stabilized in the neutral pH range, preferably for greater than about six months, more preferably for greater than about twelve months and most preferably for greater than about eighteen months. Eastman Hydroquinone, USP Grade is for skin-lightening products to address hyperpigmentation. It is understood that while the invention has been described in conjunction with the detailed description thereof, that the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. trailer << /Size 393 /Info 347 0 R /Root 375 0 R /Prev 573815 /ID[<6893db2526a970a0c364cca2e99ca522>] >> startxref 0 %%EOF 375 0 obj << /Type /Catalog /Pages 346 0 R /Metadata 348 0 R >> endobj 391 0 obj << /S 2217 /Filter /FlateDecode /Length 392 0 R >> stream Hydroquinone[1] Idrochinone Quinol 1,4-Dihydroxybenzene p-dihydroxybenzene p-hydroxyphenol 1,4-Hydroxy benzene Identifiers CAS Number 123-31-9 Y 3D model (JSmol) Interactive image Beilstein Reference 605970 ChEBI CHEBI:17594 Y ChEMBL ChEMBL537 Y ChemSpider 764 Y DrugBank DB09526 ECHA InfoCard 100.004.199 EC Number 204-617-8 Gmelin Reference 2742 Hydroquinone (C6H4(OH)2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. 0000005089 00000 n Heat Mass Transf. D7VJV//KZ&t}JSW/L@,l@^ D@ @8 i W `^;V rD}25p>.Bv1}\_E p9 endstream endobj 392 0 obj 1303 endobj 376 0 obj << /Type /Page /Parent 350 0 R /Resources 377 0 R /Contents 381 0 R /MediaBox [ 0 0 595 842 ] /CropBox [ 0 0 595 842 ] /Rotate 0 >> endobj 377 0 obj << /ProcSet [ /PDF /Text ] /Font << /TT2 379 0 R /TT4 383 0 R /TT6 385 0 R >> /ExtGState << /GS1 387 0 R >> /ColorSpace << /Cs6 378 0 R >> >> endobj 378 0 obj [ /ICCBased 386 0 R ] endobj 379 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 252 /Widths [ 250 0 408 500 0 833 778 180 333 333 500 564 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 564 564 564 444 921 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 611 333 0 333 0 500 0 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 0 0 0 541 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 333 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 400 0 0 0 0 576 0 0 0 0 0 0 0 750 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 722 0 0 0 0 0 722 0 0 500 444 0 0 0 444 0 0 0 444 444 0 0 0 0 0 0 0 0 0 0 500 0 500 0 0 0 0 0 500 ] /Encoding /WinAnsiEncoding /BaseFont /BCGIOE+TimesNewRoman /FontDescriptor 380 0 R >> endobj 380 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -568 -307 2028 1007 ] /FontName /BCGIOE+TimesNewRoman /ItalicAngle 0 /StemV 94 /XHeight 0 /FontFile2 388 0 R >> endobj 381 0 obj << /Length 462 /Filter /FlateDecode >> stream INCI HydroquinoneEastman Hydroquinone, USP is a skin care ingredient used to produce effective skin- lightening applications for depigmentation. LSPS, Laboratoire de Spectrochimie Et Pharmacologie Structurale, University of Tlemcen, BP 119, 13000, Tlemcen, Algeria, Department of Biology, University of Ghardaia, BP 455, 47000, Ghardaia, Algeria, You can also search for this author in COMMON BRAND NAME (S): Aclaro, Aclaro PD, Alera, Alphaquin HP, Alustra, Claripel, Complex B . S.C. Gad, T. Pham, in Encyclopedia of Toxicology (Third Edition), 2014 Environmental Fate and Behavior. If you are already a ChemPoint customer then sign up for access to our online ordering website. Conversion factors (at 25 oc and normal atmospheric pressure) 1 ppm = 4.5 mg!m 3
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